What is the difference between coal tar and psoriasin?
Coal tar is a by-product of coal processing. Psoriasin (for the skin) is used to treat the skin symptoms of psoriasis, including dryness, redness, flaking, scaling, and itching. Coal tar is not a cure for psoriasis, and it will provide only temporary relief of skin symptoms.
What is psoriasin and where is it found?
Psoriasin is the most abundant antimicrobial protein in healthy skin (Gläser et al., 2005 ). It also represents the principal protein in skin-washing fluid ( Gläser et al., 2005 ). We identified SC of the heel as the best natural psoriasin source.
What is psoriasin used to treat?
Psoriasin (for the skin) is used to treat the skin symptoms of psoriasis, including dryness, redness, flaking, scaling, and itching.
Will psoriasin ointment affect my hair color?
Coal tar, the active ingredient in PSORIASIN Ointment, may affect very light hair color. We recommend testing on a few strands before applying to larger areas where hair is present.
Before Taking This Medicine
You should not use this medicine if you are allergic to coal tar.Ask a doctor or pharmacist if it is safe for you to use this medicine if you have...
How Should I Use Coal Tar?
Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.Apply...
What Happens If I Miss A Dose?
Since Psoriasin is used when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Sk...
What Happens If I Overdose?
An overdose of Psoriasin is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone...
What Should I Avoid While Using Coal Tar?
Do not use coal tar together with other psoriasis medications unless your doctor tells you to.Avoid getting Psoriasin in your eyes. If this does oc...
What Other Drugs Will Affect Coal Tar?
It is not likely that other drugs you take orally or inject will have an effect on topically applied coal tar. But many drugs can interact with eac...
What are the side effects of coal tar?
Coal tar side effects. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. severe stinging, burning, swelling, or other irritation of the treated skin. Common side effects may include mild skin irritation or skin rash.
How to use coal tar shampoo?
Shake the coal tar shampoo well just before each use. Use enough shampoo to create a rich lather. Massage the shampoo into your scalp and rinse thoroughly. Apply the shampoo a second time and leave it on your scalp for 5 minutes. Rinse thoroughly.
Can you take psoriasin if you missed it?
Since Psoriasin is used when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
Can you use coal tar with psoriasis medication?
Do not use coal tar together with other psoriasis medications unless your doctor tells you to.
Is it safe to overdose on psoriasin?
An overdose of Psoriasin is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.
Can you take psoriasin if you are allergic to coal tar?
You should not use Psoriasin if you are allergic to coal tar. Ask a doctor or pharmacist if it is safe for you to use this medicine if you have other medical conditions, especially: if you are receiving ultraviolet radiation treatment for your psoriasis. Coal tar products may contain lanolin, mineral oil, or other emulsifiers.
How to determine psoriasin?
Psoriasin can be identified by SDS-PAGE giving a 10-kDa band ( Gläser et al., 2005 ). Mass determination by MALDI or ESI-MS will give an exact mass of 11,366 Da, which is different from the sequence calculated mass. Indeed, the natural psoriasin is N-terminally acetylated, missing the N-terminal Met ( Gläser et al., 2005 ). When the investigator is using a single RP-HPLC step for purification of natural psoriasin, the preparation will show an additional signal at 11,382, which comes from an oxidized (methionine-sulphoxide) psoriasin. Furthermore, there are often many different signals of psoriasin variants and/or oxidized forms present. This is markedly demonstrated by a MonoS®-HPLC of a preparative RP-8-purified psoriasin preparation, where several psoriasin variants can be identified ( Figure 8 ). This cation-exchange HPLC purification step should be included, when a pure 11,366 Da form of psoriasin is required. This elutes at 0.51 M NaCl and represents the principal peak. A subsequent C2/C18 RP-HPLC will desalt the preparation and always gives a single peak of psoriasin.
Does psoriasin cause tissue remodeling?
Recent research indicates an epidermal-dermal interaction with enhanced psoriasin formation. Found in high concentrations in wound fluid and granulation tissue, the AMP induces tissue remodeling by inhibiting the excessive production of tissue repair factors — collagen, fibronectin as well as TGF-β formation — in fibroblasts. In keloid-derived fibroblasts psoriasin production is decreased [50]. Consequently, in patients tending to develop hypertrophic scars and keloids the topical application of psoriasin may allow the suppression of keloid formation following skin injury. If existing keloids respond to topical psoriasin, is unknown. Yet, prophylaxis and cure of keloids in persons at risk opens the horizon for AMP therapy, which challenges the physician and the pharmacist. In the acute wounding psoriasin has to persist in the wound fluid. Hydrolytic enzymes in wound fluid will degrade the protein. To become active in the existing keloid, a topically applied peptide has to surmount the skin barrier and viable epidermal layers. Moreover, in order to enhance the degradation of collagen, laminin and fibronecting for tissue remodeling, the AMP has to bypass epidermal enzymes. This clearly stresses the need for adequate carrier systems for AMP delivery to the skin.
Can psoriasin be purified?
Due to its high abundance, psoriasin can be purified from SC extracts in a single RP-HPLC step. Depending upon the amounts the investigator needs for further studies, preparative or analytical RP-HPLC columns should be used. Psoriasin usually elutes as one of the last major peaks indicating it as a highly hydrophobic protein. Sometimes – when resolution of the HPLC column is low – other S100-proteins, in particular S100-A8 and -A9 as well as cystatin A, could be contaminants.
When will Cocois 40g be back in stock?
RPH confirmed that Cocois Ointment 40g is expected to return to stock in January 2022.
Why was Zorac discontinued?
In 2019, Allergan Ltd announced that the tazarotene-based topical treatment Zorac Gel had been discontinued due to business changes. There were no safety issues with the product.
Why did Thornton and Ross discontinue Aquamol?
In July 2019 we learned that Thornton and Ross Ltd had announced the withdrawal of Aquamol Emollient Cream from manufacture due to poor demand for the product.
Who makes Exorex moisturizing cream?
In March 2021 we received an enquiry from a member regarding the availability of Exorex Moisturising Cream. We contacted the manufacturer, Teva UK Limited, for an update on the availability of the product.
Who makes Exorex shampoo?
In September 2021 we contacted Teva UK, the manufacturer of Exorex Hair and Body Shampoo, to check the product's availability following reports from several of our members that it had become difficult to obtain.
When was dithrocream discontinued?
In September 2021 we were contacted by Dermal Laboratories with clarification on the availability of Dithrocream ( Dithranol) following earlier reports that all remaining strengths of the product had been discontinued (Dithrocream 2.0% was discontinued in 2020).
Details
Other Information: You may report serious side effects to the phone number provided under Questions? Below. Misc: Topical ointment. Dermatologist recommended. Stops psoriasis. Itching + scaling + redness. Can complement topical steroids. Visible results in just days. Helps prevent recurrence. New convenient tube. Contains no gluten ingredients.
Directions
Read all package directions and warnings before use. - Use only as directed. Apply (gently massage in) a small amount of PSORIASIN to affected areas. Apply one to four times daily or as directed by a doctor. Apply to thoroughly dry skin. May be difficult to wash out of hair; consider this before using on scalp or hairline areas.
Warnings
Ask a doctor before use for prolonged periods if condition covers a large area of the body around the rectum or in the genital area or groin with other forms of psoriasis therapy such as ultraviolet radiation or prescription drugs.
