What is the new titration protocol for paclitaxel?
The new titration protocol was used for every paclitaxel administration for a 3-month period. Data collected were administering nurse, date, patient initials, cycle/dose (mg), reaction, re-challenge with specific re-challenge protocol, and subsequent reaction with re-challenge.
Should you administer paclitaxel slowly or fast?
“Paclitaxel prescribing information, and our hospital policy and procedure, simply state to ‘administer slowly,’” explained Carrie Patton, BSN, RN, OCN, of Todd Cancer Institute in Long Beach, California.
Do Re-challenge protocols reduce reactions to paclitaxel infusions?
Re-challenge protocols, however, lack titration guidelines for reducing reactions associated with higher infusion rates. “Paclitaxel prescribing information, and our hospital policy and procedure, simply state to ‘administer slowly,’” explained Carrie Patton, BSN, RN, OCN, of Todd Cancer Institute in Long Beach, California.
What are the side effects of paclitaxel?
It is a taxane and a plant alkaloid natural derivative. Many patients receiving paclitaxel experience mild to severe infusion-related hypersensitivity reactions, such as uticaria, facial flushing, shortness of breath, angioedema, and anaphylaxis.
What type of container should paclitaxel be mixed in?
TAXOL solutions should be prepared and stored in glass, polypropylene, or polyolefin containers. Non-PVC containing administration sets, such as those which are polyethylene-lined, should be used 1.
How is paclitaxel made?
Taxol® (NSC 125973) Paclitaxel, the most well-known natural-source cancer drug in the United States, is derived from the bark of the Pacific yew tree (Taxus brevifolia) and is used in the treatment of breast, lung, and ovarian cancer, as well as Kaposi's sarcoma.
Does paclitaxel dissolve in water?
Paclitaxel is a broad-spectrum anticancer drug that is clinically effective against lung, liver, ovarian, breast, and other cancers. However, its solubility is less than 0.1 μg/mL in water, which seriously affects its bioavailability. Paclitaxel injection uses castor oil as the solvent for enhancing its solubility.
What is the nadir for paclitaxel?
Conventional paclitaxel: Neutrophil nadir at day 10–12, return to baseline by day 15–21. Platelet nadir at day 8–9.
What are the ingredients in paclitaxel?
Each vial contains Paclitaxel, PEG-35 castor oil, anhydrous citric acid and absolute ethanol. Paclitaxel is a natural product with antitumour activity. It is a white to off white crystalline powder that is highly lipophilic and insoluble in water.
How is paclitaxel harvested?
At present Taxol is obtained mainly from the bark of the Yew tree but scientists have found that the substance can be extracted from the needles of tree.
How do you dissolve paclitaxel?
dissolve paclitaxel in ethanol (or DMSO) at 10X the desired concentration. once in solution add an equal volume of cremophor EL, mix well then add 8 parts D5W (or saline) for a final 1X drug concentration in 10% ethanol (or DMSO), 10% cremophor, 80% D5W (or saline).
What is Taxol dissolved in?
Taxol, and Dex-TXL were dissolved in DMSO at a concentration of 1 w/v% and 1 ml of these solutions was separately mixed with 9 ml of water to check their solubility in water.
How is paclitaxel stored?
Storage: Store the vials in original cartons between 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.] Retain in the original package to protect from light.
What is the difference between paclitaxel and paclitaxel protein bound?
A form of the anticancer drug paclitaxel that is used alone or with other drugs to treat certain types of breast cancer, non-small cell lung cancer, and pancreatic cancer. Protein-bound paclitaxel may have fewer side effects and work better than other forms of paclitaxel.
What is the difference between Taxol and paclitaxel?
Paclitaxel is a chemotherapy drug. It is a treatment for many different types of cancer. It is also called Taxol.
All Answers (2)
There are hundreds of publications freely available in scientific databases and detailing how using paclitaxel in vitro.
Similar questions and discussions
Is there any problem with the stability of Paclitaxel in culture medium?
Introduction
Culture should be approximately 90% confluent prior to preparation of frozen stock in order to insure the highest number of viable cells from reviving a frozen culture.
Protocol
Trypsinize cells as mentioned in the Subculturing Protocol (Steps 1-4).